Creatinine Detection
| Test Mnemonic | Urine Creatinine |
|---|---|
| CPT Code | 80307 |
| Also Known As | Creat |
| Specimen Type | Urine |
| Specimen Container | Plastic container w/ tightly fitting cap |
| Alternate Speciman Type | None |
| Preferred Volume | 1.0 mL |
| Minimum Volume | 0.5 mL |
| Specimen Collection | Routine voided urine collection |
| Specimen Process | Collect freshly voided urine in plastic containers |
| Specimen Transport Storage | Refrigerated |
| Specimen Stability | 7 days room temperature (18-30°C); 3 days refrigerated (2-8°C); 3 months frozen (-20°C or less) |
| Specimen Rejection | • Improperly labeled. • Incomplete information on the requisition. • Too old for processing. • Failure to meet volume criteria. • Leaking primary or secondary specimen container. • Wrong collection container for test ordered. • Gross contamination. • Improper storage |
| Methodology | Enzyme Immunoassay |
| Use | For the quantitative determination of creatinine in human urine for the detection of urine adulteration by dilution or substitution with non-urine in solution. |
| Clinical Signifigance | A complete urine drug abuse testing program normally involves specimen collection, initial screening with immunoassay, followed by a confirmation test, such as gas chromatography/mass spectrometry, for positive samples. Many drug users attempt to evade detection by adulterating their specimen to produce false negative results during the initial immunoassay screening. Adulteration methods include dilution with water, substitution with a drug free liquid, addition of readily available household materials, or tampering with certain chemicals. Creatinine is secreted from muscle into urine daily. In the absence of renal disease, the rate of creatinine clearance in an individual is relatively constant. Dilution of urine with water or any other non-urine solution can result in a lower creatinine concentration. |
| Reference Range | >20 is Unadulterated |
| Day Run | Mon-Fri |
| Time Run | As Received |
| Time Reported | 3 days |
| Test Type | Tox |
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